Interestingly, in the era before the approval of ARSTAs, including abiraterone acetate and enzalutamide, most CRPC were AR-dependent PC (88.4%) with rare NEPC (6.3%) and DNPC (5.4%), although tumor phenotypic changes with a higher percentage of DNPC (23.3%) were observed in the contemporary era [1]. This evidence concerns the gene AR and pachyonychia congenita.