In addition, we found specific AD enzyme redistribution patterns: CuZnSOD in mitochondria at the mitochondrial cristae and peroxisomal membrane; MnSOD in the peroxisomal matrix, CAT in the mitochondria, and GSH-Px in and around lipid bodies (membrane monolayer), suggesting enzyme subcompartmentalization in fine-tuning of AD in brown adipocytes during hypothyroidism. The gene discussed is CAT; the disease is hypothyroidism.