In addition, invasive endometrial tumor with PTEN (phosphatase and tensin homolog) /LKB1(liver kinase B1)-deficiency displays dysregulated Lkb1/Ampk and phosphatidylinositol 3-kinase (PI3K)/Akt signaling with intensive mTOR signaling [34]. This evidence concerns the gene PTEN and endometrium neoplasm.