PODXL and focal segmental glomerulosclerosis: In the podocytes of FSGS, elevated expression of microRNA-193a reduced WT1 expression and thereby downregulated target genes of WT1 that are vital to podocyte structure, including PODXL (podocalyxin), NPHS1 (nephrin), VEGFA (VEGFA), etc., eventually leading to kidney disease and proteinuria [61].