For example, the expression levels of VEGFA and VEGFR2 were significantly increased in early diabetic nephropathy, the inhibition of the VEGFA/VEGFR2 pathway attenuated proteinuria [29], while in patients taking TKIs, the expression levels of VEGFA and VEGFR2 were lower than normal [17,28], which is the opposite of diabetic nephropathy. This evidence concerns the gene KDR and diabetic kidney disease.