In the early stage of diabetic kidney disease, the expression of ANGPT1 in the kidneys was upregulated and returned to the control level or lower in the later stage [36]; podocyte-specific inducible repletion of ANGPT1 in early diabetic kidney disease reduced albuminuria [43], indicating a protective role of ANGPT1 for the kidneys, which may be attributed to the anti-inflammatory effect and the maintenance of vascular integrity mediated by ANGPT1. The gene discussed is ANGPT1; the disease is diabetic kidney disease.