Thirty two percent of patients with RA experience rheumatoid cachexia, as a result of joint destruction, subsequent muscle inactivity, high levels of sarcoactive inflammatory cytokines—incl tumor necrosis factor α (TNF) -α and interleukin (IL) 1β, loss of muscle mass and strength and the accompanying increase in fat mass are very common in patients with rheumatoid arthritis. Here, TNF is linked to rheumatoid arthritis.