In this study, we found that resveratrol enhanced the inhibitive effects of cisplatin on P-AKT, P-PI3K, Smad2, Smad3, P-JNK, P-ERK, and NF-κB expressions in MDA231 xenografts (Figure 6) indicated that the regulations of P-AKT, P-PI3K, Smad2, Smad3, P-JNK, P-ERK, and NF-κB expressions may be involved in resveratrol enhances anti-tumor of cisplatin in MDA231 xenografts. This evidence concerns the gene SMAD3 and neoplasm.