Therein, resveratrol-based combinatorial strategies for cancer management has also been increasingly studied, that showed resveratrol sensitizes tamoxifen in antiestrogen-resistant breast cancer cells [11] and TNF-β-induced survival of 5-FU-treated colorectal cancer cells [31], increases arsenic trioxide-induced apoptosis in chronic myeloid leukemia cells [32] and lung cancer cells [33], decreases cytotoxicity of doxorubicin in breast cancer cells [15], and combined with piceatannol upregulates PD-L1 expression in breast and colorectal cancer cells [34]. Here, CD274 is linked to colorectal cancer.