MKI67 and neoplasm: We observed that age (hazard ratio (HR):2.280, p = 0.004), tumor site (HR:1.834, p = 0.047), mitotic index (HR:4.553, p = 0.000), necrosis (HR:3.258, p = 0.000), Ki-67 (HR:0.553, p = 0.000), invasive depth (HR:2.051, p = 0.003), FNCLCC grade (HR:4.886, p = 0.001) and surgical margin (HR:2.327, p = 0.011) were significantly associated with OS in UPS (Table 2).