Zhang et al. [108] has recently conducted preclinical studies in mice models with PCa tumours and demonstrated that triple therapy of streptavidin-GM-CSF surface-anchored tumour cell (anchored GM-CSF) vaccine, anti-TIM-3 and anti-PD1 antibodies in sequential pattern inhibited tumour growth and increased tumour regression rate in more than 60% of tested mice. This evidence concerns the gene PDCD1 and neoplasm.