LEP and Insulin resistance: These cytokines include adipokines induced by inflammation, such as leptin, adiponectin, tumor necrosis factor-alpha (TNF-α), interleukin 1 (IL-1), and IL-6; coagulants, such as PAI-1; vasoactive substances, such as leptin, angiotensinogen, and endothelin; and molecules such as FFA, TNF-α, and resistin that may cause insulin resistance.