BCL2 and cancer: Since the survival of cancer cells is heavily promoted by anti-apoptotic BCL-2 family members, such as BCL-2 (B cell lymphoma-2) and MCL-1 (myeloid cell leukemia-1), which prevent malignant cells from the mitochondrial cell death pathway [12], targeting both mitochondrial respiration and intrinsic apoptotic processes may suggest more potent therapeutic strategies.