In fact, histamine H3 receptor ligands that might inhibit oxidative stress by reducing free radical concentrations have been shown to have potential therapeutic applications in several neurological disorders, such as Parkinson’s [12], Alzheimer’s disease [13], cerebral ischemia/stroke [14], depressive illness [15], epilepsy [16,17], schizophrenia [18], autism [19], and cardiovascular disorders, such as myocardial infarction [20]. The gene discussed is HRH3; the disease is nervous system disorder.