The incubation of cisplatin-treated Saos2 osteosarcoma cells with a PLK2 inhibitor or PLK2 depletion using siRNA increases the expression of the p21WAF1 and PUMA genes, inhibits cell proliferation and cell invasion, arrests the cell cycle at the G1 phase, and induces apoptosis, thus indicating that PLK2 phosphorylates p73 and inhibits p73 transcriptional activity [100]. Here, TP73 is linked to osteosarcoma.