The main genetic driver mutations associated with these disorders are mutations of the genes encoding Janus kinase 2 (JAK2), or calreticulin (CALR), the Bcr-abl mutation, which is closely associated with CML, and by a truncated form of the thrombopoietin receptor gene [63]. This evidence concerns the gene JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive.