SIRT1 (Sirtuin1), a class III histone deacetyltransferase and a nicotinamide adenine dinucleotide-dependent deacetylase, exerts protective effects against oxidative stress, genomic instability, and DNA damage, and SIRT1 overexpression may play a crucial role in the tumorigenesis of BOTs and the carcinogenesis of early-stage ovarian cancer [88,89,90]. The gene discussed is SIRT1; the disease is ovarian carcinoma.