CD2 and acute lymphoblastic leukemia: Other studies have shown that CD2 negativity correlated with the immature T-cell receptor and TCRγδ T-ALL lineages, which are associated with the occurrence of the CALM-AF10 fusion gene and the TLX3/HOX11L2 and MLL(KMT2A) gene rearrangements, considered to be prognostically unfavorable [26,27,28].