Our analyses strongly suggest that ALK signaling regulates RET transcription predominantly through the RAS/MAPK signaling arm, and the results are in keeping with later findings investigating ALK and RET in NB [37], with characterization of a Th-MYCN/RetM919T mouse model in which oncogenic cooperation between activated Ret and MYCN overexpression resulted in NB that displayed similarities with Th-MYCN/Alk_F1178L tumors. Here, MYCN is linked to neuroblastoma.