Moreover, protein expression levels assessed by flow cytometry in seven MDS patients (n = 4 MDS-multilineage dysplasia (MLD), n = 2 MDS-excess blasts 1 (EB1), n = 1 MDS-excess blasts 2 (EB2)) and six controls showed up-regulation of both HIF-1α and REDD1 peptides in MDS CD34+ and differentiating myeloid cells, yet with significance established only in the latter group (Figure 1A,B,D,E). The gene discussed is DDIT4; the disease is metachromatic leukodystrophy.