HIF1A and myelodysplastic syndrome: Results of the present study come to confirm our data with the benign MDS subtypes suffering marked degradation of their dysfunctional mitochondria, leading to pseudohypoxia and HIF-1 stabilization while as disease progresses, genetic or epigenetic pressure leads to compensatory changes in mitochondrial function, and kinetics that remain faulty cause HIF-1 stability but are also rescued from degradation.