CBD suppresses the proliferation and infiltration of T cells and macrophages in the tumor microenvironment, reduces the production of pro-inflammatory cytokines—such as interferon-γ (IFN-γ), interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α)—and increases that of immune-suppressive cytokines, such as interleukin-10 (IL-10), in vitro and for in vivo models [105]. The gene discussed is TNF; the disease is neoplasm.