COX-2 inhibitor (NS-298) and PPAR-γ antagonist (GW9662) studies in lung cancer cell lines (A549, H460) and primary lung cancer cells have demonstrated that CBD-induced apoptosis is associated with an upregulation of the pro-apoptotic markers, COX-2 and PPAR-γ [78]. This evidence concerns the gene PTGS2 and lung cancer.