TIMP1 and neoplasm: The intercellular adhesion molecule-1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), which are frequently decreased in tumor cells upon treatment, are up-regulated by CBD, whereas an opposite trend is detected for matrix metalloproteinases (MMPs) in lung cancer cells, which obstruct tumor cells’ ability to pass through complex extracellular matrices [97] (Table 2).