It is reported that NEIL3 can promote the repair of interstrand crosslinks [12], drive autoimmunity [13], suppress apuricic/apyrimidinic endonuclease 1 (APE1) [14], etc. Here, we found lower NEIL3 in CRPC and chemotherapy-resistant prostate cancer, and found low NEIL3 to be associated with a poor prognosis. This evidence concerns the gene NEIL3 and Familial prostate cancer.