The major subtypes in children and adolescents are the mature B-cell lymphomas Burkitt lymphoma/leukemia (BL, B-AL, 45%) and diffuse large B-cell lymphomas (DLBCL, 10%), lymphoblastic lymphomas (LBL, 20%) and ALK-positive anaplastic large cell lymphomas (ALCL, 15%) [1]. This evidence concerns the gene ALK and diffuse large B-cell lymphoma.