By contrast, hepatocellular iron excess in mouse models of hemochromatosis (such as Hfe−/−, Hjv−/−, and Hfe−/−/Hjv−/− double knock-out) did not aggravate diet-induced steatosis to steatohepatitis or early liver fibrosis [145]. The gene discussed is HFE; the disease is hemochromatosis type 1.