CYP2C19 and Anxiety: CYP2C19 and CYP2D6 variants affect the occurrence of ADRs in patients treated with selective serotonin reuptake inhibitors (SSRIs)(citalopram, escitalopram, sertraline, fluvoxamine, fluoxetine, paroxetine), including anxiety associated with CYP2D6, and ECG prolonged QT intervals associated with CYP2C19 [68].