APOE and Anxiety: Baseline values of anxiety (HARS-0) were significantly different between APOE-2/3 and 2/4 (p < 0.007); APOE-2/4 vs. 3/3 (p < 0.01), vs. 3/4 (p < 0.002), and vs. 4/4 (p < 0.001); and APOE-3/3 vs. 3/4 (p < 0.005) and vs. 4/4 (p < 0.02) (Table 2; Figure 4).