Our study demonstrates that a multifactorial regime, covering biochemical and metabolic deficiencies, together with neuroprotectants and adjusted psychotropic medication, can be beneficial for emotional stability in AD patients, and that APOE-4 carriers and CYP-related PMs and UMs, representing over 40% of the AD population, deserve special attention for their vulnerability and poor response to current treatments. Here, APOE is linked to Alzheimer disease.