Cancer cells with PTEN expression have been shown to have a more favorable response to chemotherapy; however, overexpression of miR-130a may upregulate the proliferation of chemo-resistant cancer cells by inhibiting PTEN expression and, consequently, activation of the PI3 K/AKT signal pathway that increases BCL-2 expression to decrease tumor cell apoptosis. This evidence concerns the gene AKT1 and neoplasm.