While the pathogenesis of IgG4-RD remains unclear; previous research noted that upregulation of cytokines secreted from T-helper 2 (Th2) and regulatory T (Treg) cell, including interleukin (IL) 4, IL-5, IL-10, IL-13, and transforming growth factor-beta 1 (TGF-β1) has been considered to play the crucial role in the onset of the disorder, causing the proliferation of IgG4- plasma cells [5]. This evidence concerns the gene TGFB1 and immunoglobulin G4-related sclerosing disease.