For instance, in models of abdominal aortic aneurysm, a vascular disease associated with the overexpression of MMP-2 [104], doxycycline concentration-dependently inhibited the secretion of MMP-2 in cultured human smooth muscle cells and abdominal aortic aneurysm explants [104], which was accompanied by a reduction in the half-life of MMP2 mRNA from 49 h to 28 h [104]. The gene discussed is MMP2; the disease is abdominal aortic aneurysm.