In particular, induction of miR-486-5p suppressed MMP-2 and MMP-9 protein expression in human colorectal cancer cell lines [110] as well as in human lung adenocarcinoma cell lines [111], suggesting that an epigenetic mechanism by which doxycycline affects MMP expression occurs via the induction of miR-486. The gene discussed is MMP2; the disease is lung adenocarcinoma.