To further demonstrate the role of non-histone proteins in mediating the regulation of HDAC on MMP expression, Liu et al. (2003) reported that upregulation of the reversion-inducing-cysteine-rich protein with kazal motifs (RECK), a reported tumor invasion and angiogenesis suppressor [65], induced by HDAC inhibition downregulates the activation of MMP-2 [66]. The gene discussed is HDAC9; the disease is neoplasm.