HIF1A and neoplasm: The heterodimeric HIF-1α/β binds to the hypoxia-responsive elements to initiate the transcription of downstream target genes including BNIP3, LDHA, PKM2, EPO, and VEGF [15], thus triggering tumor progression, dissemination, metastasis, and chemoresistance in multiple cancers such as colorectal cancer, breast cancer, cervical cancer, glioma, and pancreatic cancer [16,17,18,19,20].