PHLPP1 and type 2 diabetes mellitus: In our study, PHLLP1 expression was reduced in OB GDM(−) placental tissues compared to NW, while it resulted in being significantly increased in OB GDM(+) compared to OB GDM(−), supporting a correlative hypothesis between PHLPP1 activity and GDM, as already hypothesized in type 2 diabetes by Andreozzi and colleagues [49].