Specific MHC bound tumor neoantigen peptides are then recognized by the unique T-cell-Receptor (TCR) [104] of these anti-tumor cells (6) allowing for tumor cell-specific killing (6) which propagates the cycle as phagocytic dendritic cells and/or macrophages take up the released cancer cell antigens in the process of clearing apoptotic cell debris. This evidence concerns the gene HLA-C and neoplasm.