Another interesting example is the dual inhibition of aldose reductase (AR, IC50 0.056 μM) and protein tyrosine phosphatase 1B (PTP1B, IC50 32.5 μM) by a (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivative with the potential to treat T2DM [13]. Here, PTPN1 is linked to type 2 diabetes mellitus.