Gao et al. showed that the serum levels of NT-proBNP, which is one of the markers of heart failure, were correlated with in-hospital mortality in patients with COVID-19, and were also significantly associated with the serum levels of systemic inflammation and elevated myocardial injury markers, suggesting that this parameter could be useful as one of the indicators of the severity of COVID-19 [92]. This evidence concerns the gene NPPB and COVID-19.