VEGFA and neoplasm: Moreover, targeting nonimmune components of the tumor microenvironment by normalizing or decompressing the vasculature with anti-VEGF antibodies and renin-angiotensin system inhibitors, respectively, represents a clinically translatable strategy to overcome resistance to immune checkpoint blockers [38,40,41] Compression MR elastography, as developed in our study, might prove useful to assess the normalization of the tumor biomechanical properties, including solid stress, by these treatments.