KRT14 and Hyperkeratosis: Keratinocyte differentiation is defective and results in parakeratosis alternating with hyperkeratosis [1,2], while the downregulation of several differentiation markers [3], as well as high expression of basal markers keratin 14 (K14) and K17 in the suprabasal layers [4,5] have been proposed as a prognostic factor for the progression to SCC.