TOR1A and Dystonia: A convincing demonstration of convergence on striatal cholinergic dysfunction in dystonia was provided recently by Eskow Jaunarajs et al. who used three genetic approaches (Tor1a, Thap1, and Gnal) and saw remodeling of D2 DA receptor signaling in striatal ChINs in all models, as a result of overactive mAChR signaling [245].