α-Thrombin, activation of PAR1 induces the receptor to couple to the G protein subunits Gαq or Gα12/13 to induce activation of the proto-oncogene tyrosine-protein kinase c-Src (Src short for sarcoma) and subsequent activation of the E3 ubiquitin ligase, neural precursor cell expressed developmentally downregulated 4-2 (NEDD4-2) [32]. The gene discussed is SRC; the disease is sarcoma.