Ovarian cancer cells (A2780) treated with different icariin concentrations inhibited cell proliferation, accelerated apoptosis, and caspase-3 activity by targeting phosphatase and tensin homolog (PTEN), reversion-inducing cysteine-rich protein with kazal motifs (RECK), and Bcl-2 protein expression in A2780 cells [99]. Here, PTEN is linked to ovarian carcinoma.