It has been shown that SIRT6 overexpression favors hepatoma cell proliferation through the extracellular signal-regulated kinases 1/2 (ERK1/2) pathway [183,185], whereas SIRT2 plays a critical role in promoting HCC metastasis and invasion rather than cell growth by re-routing liver cancer metabolism [182]. The gene discussed is SIRT6; the disease is hepatocellular carcinoma.