PPARA and metabolic dysfunction-associated steatohepatitis: The mito-DAMPs-induced inflammation, combined with mitochondrial oxidative damage within hepatocytes, further modulates the efficacy of nuclear receptors, such as liver X receptors (LXRα, LXRβ) and members of the PPAR family (PPARα, PPARβ, PPARγ), which are key regulators of mitochondrial activity (i.e., β-oxidation) and may be crucial in NASH progression.