MFN1 reduction was correlated either with EMT and the reprogramming of glucose metabolism alongside vascular invasion and poor outcome in HCC patients [77], while MFN2 overexpression induced cell death by enhancing cytochrome c release, Ca2+ entry and lowering mitochondrial membrane potential in HepG2 cells, thus inhibiting HCC cell growth [153,154]. This evidence concerns the gene CYCS and hepatocellular carcinoma.