VSIR and autoimmune disease: Regarding interactions between key Bacteroidetes species and the intestinal immune response, ITGAE is involved in not only intestinal damage but also systemic tissue damage associated with inflammatory diseases, including autoimmune diseases [31,32,33], and C10ORF54 is a potent negative regulator of T cell function, being expressed on hematopoietic cells and leukocytes [34].