For instance, exosomes released by glioblastoma multiforme (GBM) cells harboring the PTPRZ1-MET fusion (ZM fusion) have high levels of the proto-oncogene MET and induce resistance to the alkylating agent temozolomide by promoting migration, invasion, and epithelial-mesenchymal transition (EMT) in GBM cells [54]. The gene discussed is PTPRZ1; the disease is glioblastoma.