Conversely, in tumor cell lines, the import of ATP and the so-called matrix conformation of ANT are favored; therefore, the ANT2 isoform can be a direct inhibitor of the PTP function of ANT [67] and then considered an anti-apoptotic oncoprotein [68,69] that functions as an inhibitor of mitochondrial membrane permeability. This evidence concerns the gene SLC25A4 and neoplasm.