SLC25A4 and heart failure: Consistently, in transgenic rats overexpressing ANT1 in the heart and crossed with renin-overexpressing rats suffering from hypertension-induced cardiac insufficiency, [137] showed that an accelerated ATP/ADP transport across the mitochondrial membrane improves mitochondrial structure and function, leading to a reduction in fibrosis and an improvement in cardiac tissue architecture, and thus may be a basic principle for new strategies in treating heart disease.