MAPT and Alzheimer disease: Since Yang and Ksiezak-Reding [163] showed that as a consequence of glycation, paired helical filament-tau from AD and advanced glycation end-tau generate oxygen free radicals and since Cente et al. [164] reported that expression of a human truncated variant form of tau protein leads to the accumulation of ROS, the possibility that ANT impairment derives from ROS–protein interaction as well as from protein–protein interaction has been considered.