Indeed, in aging WKYRs we found a reduced ANT activity in accordance with the altered ANT activity and expression already observed in a variety of human heart failure [136,137]; contrarily, in SHRs the rate of ATP supply outside mitochondria in vitro increased by 300–600% in the physiological ADP concentration range (20–60 μM) [138]. This evidence concerns the gene SLC25A4 and heart failure.