More evidence of impaired NCT can be noticed in HD iPSC-derived neurons, including a significant decrease in the nuclear to cytoplasmic ratio of endogenous Ran, and an increase of the nuclear concentration of microtubule-associated protein 2 (MAP2) that normally localize in the cytoplasm, and the decrease of both RanGAP1 and Nup62 expression [13]. This evidence concerns the gene RAN and Huntington disease.