TP53 and cancer: Similarly, the Asian Cancer Research Group (ACRG) has characterized gastric adenocarcinoma into four subtypes: tumors with microsatellite stable/epithelial-to-mesenchymal transition (MSS/EMT), tumors with microsatellite instability (MSI), microsatellite stable/TP53 activity (MSS/TP53+) tumors, and microsatellite stable/TP53 inactivity (MSS/TP53-) tumors [133,134].