RPS6KB1 and obesity due to melanocortin 4 receptor deficiency: This finding points to a new, kinase-independent role of S6K1 and could shed new light on the pathomechanism of disorders associated with dysregulation of S6K1 and autophagy, such as obesity, insulin resistance, neurodegenerative diseases, myopathies, and cancer [3,19,21,22,23,24].