RPS6KB1 and Familial prostate cancer: Previously, using prostate cancer cells (PC3) with silenced S6K1 expression and S6K1/2 double-knockout mouse embryonic fibroblasts (S6K DKO MEF), we showed that in cells devoid of S6K1, while the efficiency of lysosomal degradation of the autophagosome (autophagic flux) is not perturbed under basal conditions, it is impaired under stress conditions induced by serum deprivation or by sulforaphane (SFN) [30].