IFNG and neoplasm: Co-expression of T cell and myeloid markers in cluster 1 tumors is in agreement with the heterogeneous immune contexture described to occur in three tumor immune subtypes defined as “would-healing”, “IFN-g dominant” and “inflammatory”(across several histologies) by Thorsson et al. [20] These evidences indicate that a “hot tumor” (a lesion where spontaneous development of immunity has occurred) is not necessarily characterized only/mainly by infiltration of potentially “anti-tumor” T cells and such tumors are also characterized by the strong presence of myeloid cells.