CDKN1B and carcinoma: In hormonal receptor- positive carcinoma, lower p27Kip1 was correlated with decreased overall survival [hazard ratio (HR) = 1.42; 95% confidence intervals (CI) = 1.05 to 1.94; disease-free survival HR = 1.27; and 95% CI = 0.99 to 1.63], as compared to carcinoma with higher p27Kip1 expression treated with adjuvant therapy (doxorubicin and cyclophosphamide) [90].