It has been also shown that TIM-3 is present in different STS and exerts immunosuppressive functions through different mechanisms, which are (i) the decrease in proliferation and secretion of pro-inflammatory cytokines by TIL, (ii) the induction of anergic T cells related to the presence of CD163+ M2 macrophages in TME, (iii) the up-regulation of epithelial–mesenchymal transition markers and (iv) the induction of the proliferation of tumor cells, thus suggesting that TIM-3-blocking antibodies may inhibit tumor growth [175,176,177,178]. This evidence concerns the gene CD163 and neoplasm.