TGF-β1, in particular, is produced by different cell populations, including tumor cells, endothelial and stem cells and fibroblasts, and (i) supports the growth and activities of CAF, (ii) stimulates angiogenesis and (iii) inhibits the functions of granulocytes, lymphocytes and antigen-presenting cells [3]. The gene discussed is TGFB1; the disease is neoplasm.