Although the presence of TIL had a positive clinical impact in high-risk NB patients [109], Melaiu and coworkers [110] correlated a worse prognosis in NB patients with the presence of PD1+ and LAG3+ TIL and a high density of PD-L1+ and HLA class I+ tumor cells in the TME. The gene discussed is CD274; the disease is neuroblastoma.