In addition, both IL-10 and TGF-β1 display immune-modulatory activities through different mechanisms including (i) activation of Treg cells recruited into the tumor, (ii) induction of a shift in the Th1–Th2 balance towards Th2 phenotypes without cytotoxic function, (iii) inhibition of Th1 responses, (iv) decrease in M1 activities paralleled by the stimulation of M2 functions and (v) induction of chemokine production (e.g., macrophage chemo-attractant protein 1) [4,5]. This evidence concerns the gene IL10 and neoplasm.