PD-L1 tumor expression failed to show sufficient specificity to exclude a possible therapeutic response associated with anti-PD1 immunotherapies, with ORRs ranging from 13% to 41% in PD-L1-negative patients treated with nivolumab alone, and even 55% in PD-L1-negative patients treated with the nivolumab-ipilimumab combination [27]. The gene discussed is CD274; the disease is neoplasm.