As NEU-1 activity is implicated in the development of diabetes and as the leaves of O. latifolia are used to treat several pathologies such as diabetes, feddeiketone B (1), 2,3-Dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone (2) and syringylglycerol (3) have been selected for this study due to their structural analogy with DANA. Here, NEU1 is linked to diabetes mellitus.