The mRNA expression of Interferon-τ (IFNT), IFN stimulated genes (ISG15, CTSL1, RSAD2, SLC2A1, CXCL10, and SLC27A6), Peroxisome proliferator-activated receptors (PPARA, D, and G), and Retinoid X receptors (RXRA, B, and G) genes and proteins (IFNT, ISG15, CXCL10, PPARG, RXRG, SLC2A1, and SLC27A6) were lower and MUC1 at mRNA and protein levels, was greater in gestation day (GD) 16 embryo and corresponding endometrium of subclinical endometritis cows, and in cows following transfer of poor quality embryo (Grade 3). Here, ISG15 is linked to endometritis.