TRIB3 and hereditary clear cell renal cell carcinoma: In the same way, in renal cell carcinoma [8], gastric cancer [9], oral tongue squamous cell carcinoma [10], and non-small-cell lung carcinoma [11], the upregulated TRIB3 expression correlates with tumor stage, lymph node metastasis, disease recurrence, and thus with unfavorable prognosis.