CTLA4 and non-small cell lung carcinoma: The most important studies on CTLA-4 pathways have been conducted by Ehlerding et al. [87,88], which investigated the capacity to visualize CTLA-4 expression in a NSCLC humanized mouse model by in-vivo [64Cu]DOTA-ipilimumab, [64Cu]NOTA-ipilimumab and [64Cu]NOTA-ipilimumab-F(ab’)2 PET images.